Showing posts with label vaccines. Show all posts
Showing posts with label vaccines. Show all posts

Thursday, 9 June 2011

POVERTY: MADAGASCAR: Vaccination efforts pay off

ANKAREIRA, 9 June 2011 (IRIN)

 Photo: Hannah McNeish/IRIN
Waiting for vaccinations at the clinic in Akareira

 Tahiri and her baby daughter have joined a courtyard full of women sheltering their babies from the midday sun at a health centre in Ankareira, near Madagascar's southern tip.
"I had a two-year-old and a three-year-old child and they both got sick and then died, one after the other," she said.
Tahiri, who grows rice and manioc in one of the poorest, most drought-affected regions of the country, does not know what illnesses killed her first two children, but she has brought her daughter to the clinic to be vaccinated because she wants to give her the best chance "to have good health".
Madagascar has reduced its under-five child mortality rate by more than 60 percent over the last decade. Part of that success has been down to increased vaccine coverage, with the World Health Organization and UN Children’s Fund (UNICEF) estimating that 78 percent of the country's children were immunized in 2009, compared to 57 percent in 2000.
That increase was made possible partly as a result of funding from the Global Alliance of Vaccines and Immunization (GAVI), a public-private partnership launched in 2000 to improve access to vaccines in developing countries such as Madagascar, where it has contributed US$56.5 million.
GAVI says its support to NGO and public health programmes which deliver vaccines has saved five million children from premature death over the last decade, and that it can save four million more over the next four years by doubling the number it helps immunize to half a billion and introducing two new vaccines.
To do this GAVI estimates it will need $6.8 billion, but so far donors have only promised to fund about half that amount. GAVI hopes to raise the remaining $3.7 billion at a pledging conference in London on 13 June.

Cost-effective
"For a long time vaccines were unavailable in the developing world, in countries such as Madagascar, either because the appropriate vaccines for these kinds of countries and conditions didn't exist, or because they were too expensive," said GAVI spokesman Ed Harris on a recent visit to Madagascar.
Harris said that while countries like Madagascar clearly needed development in many sectors, vaccines were one of the most cost-effective interventions.
His comments are supported by findings from two studies conducted at the Johns Hopkins Bloomberg School of Public Health in Baltimore published in the June issue of Health Affairs. Both studies project that boosting efforts to develop and deliver vaccines could not only save the lives of 6.4 million children but save $6.2 billion in treatment costs, and achieve $145 billion in long-term economic gains by avoiding the lost productivity resulting from premature death.
UNICEF Madagascar representative Bruno Maes said now more than ever, support from organizations like GAVI was vital as Madagascar continues to feel the effects of a protracted political and economic crisis which started in 2008 and has caused poverty levels to increase and government spending on health to drop from $8 to $2 per person.
"This is a drastic reduction for essential services for children, and we are very concerned about their vulnerability," said Maes.
According to UNICEF, which was one of GAVI's founding partners, 38,000 Malagasy children under the age of five still die every year and under-funding of the health sector has started to reverse some of the country's immunization gains. Coverage for measles vaccination, for example, has fallen from 2007 levels of 81 percent to 64 percent in 2010.
Marie-Josephine Hantomalala, head of the clinic in Ankareira which does vaccinations twice a week, is worried she will have to turn away the crowd of women and their children waiting outside, many of whom left their homes at dawn to reach the clinic by foot.
"The fridge for the vaccines has broken down and the temperature has dropped to 19 degrees," she said, adding that a vaccines expert in the nearest city, over two hours drive away, could not respond to her call for assistance because he lacked petrol.
In addition to providing affordable vaccines to Madagascar, GAVI has spent almost $10 million on strengthening the health system to deliver them in remote rural clinics that often lack the kerosene to run fridges needed for vaccine storage.
District Doctor Andriatsararanto Rabetsivahiny, who works in the Amboasary-Sud region of southeastern Madagascar, said in an area where over 130,000 people live more than 5km from the nearest health centre, initiatives to increase vaccine coverage had greatly helped reduce child mortality.
While malaria and diarrhoea were still major causes of deaths in children, deaths from measles were much less common than previously. He added that the biggest killer was malnutrition as undernourished children were vulnerable to attack from a number of diseases and often too weak to survive them.
He said in an area with little cultivatable land and high unemployment, "in times of difficulty people live off tamarind mixed with ash and water - morning, noon and night, just to survive".

Two new vaccines in pipeline
Manjarasoa, 18, has walked for an hour with her one-year-old baby to reach the Ankareira clinic.
"It's been five days since he's had diarrhoea. I've been feeding him herbal tea but it just hasn't stopped," she said.
Since 2001, GAVI has helped immunize children against tetanus, diphtheria, hepatitus B and pertussis (whooping cough) using the tetravalent vaccine. The introduction of the pentavalent vaccine in 2008 added protection against Haemophilus influenzae type B (Hib).
Now GAVI, along with UNICEF and other partners, wants to help developing countries introduce two new vaccines. The first would protect children from pneumococcal disease, the leading cause of pneumonia, and the second would provide protection from rotavirus, the most common cause of severe diarrhoea. Pneumonia and diarrhoea are the two leading killers of children under the age of five, causing nearly 40 percent of all childhood deaths.
"Children in rich countries don't die from diarrhoea," pointed out Shanta Bloemen from UNICEF South Africa, while children in the poorest most remote areas who could not easily be reached with treatment were vulnerable.
"If every child is vaccinated you're giving them the primary foundation to survive the first few years of life when they are most vulnerable to disease and have weak immune systems, and in Madagascar... almost half the children are malnourished so they are vulnerable," she told IRIN.
Madagascar has been earmarked among the developing countries which could benefit from GAVI funding for pneumococcal and rotavirus vaccines, but the availability of financing will depend largely on the success of the pledging conference and on the price of the vaccines coming down. In response to a recent tender by UNICEF, which procures the majority of vaccines funded by GAVI, Merck & Co and GlaxoSmithKline have significantly reduced the price of their rotavirus vaccines.
With a child dying every 20 seconds from a vaccine-preventable disease, Harris said: "At stake on 13 June are potentially millions of lives."
http://www.irinnews.org/report.aspx?reportID=92939

Sunday, 30 January 2011

BIOTERRORISM: New Discovery Could Lead to Vaccines for Plague and Bacterial Pneumonia


There is an ongoing battle in the "war on terror" that remains mostly unseen to the public -- a race between scientists working to develop a vaccine to protect against plague and the terrorists who seek to use plague as a weapon.
"Governments remain concerned that bioweapons of aerosolized Yersinia pestis, the bacteria that causes plague, could kill thousands," says Stephen Smiley, a leading plague researcher and Trudeau Institute faculty member.
The anthrax scare that followed the terror attacks of September 11, 2001, made the threat of bioterrorism real and led to a surge in federal funding into research aimed at heading off such threats.
According to Smiley, there is no licensed plague vaccine in the United States. Together with postdoctoral associate Jr-Shiuan Lin, he is working to develop a vaccine that will protect members of the armed services and public from a "plague bomb."
Yersinia pestis is arguably the most deadly bacteria known to man. Plague infections of the lung, known as pneumonic plague, are extremely lethal. The bacteria, which grow both inside and outside the cells of the lung, usually lead to death within a week of infection.
Most of the plague vaccine candidates that have been studied aim to stimulate B cells to produce plague-fighting antibodies. However, animal studies suggest that antibodies may not be enough to protect humans from pneumonic plague. The Smiley laboratory has shown that T cells can also fight plague. The lab previously demonstrated that a single immunization with an experimental vaccine stimulates the production of T cells that provide partial protection against pneumonic plague.
New data, reported in the current issue of the Journal of Immunology, show that a second immunization, or booster, improves the protection provided by T cells. "It is particularly exciting that the boost seems to improve protection by increasing a newly described type of T cell, which we call a Th1-17 cell," says Smiley. These cells have characteristics of both Th1 cells, which defend against intracellular bacteria, and Th17 cells, which specialize at killing extracellular threats.
This research is focused primarily on thwarting the use of plague as a bioweapon. However, small, natural outbreaks of plague continue to this day. A plague vaccine will protect against both naturally occurring outbreaks and those that have been manufactured.
Additionally, Smiley believes these Th1-17 cells may be important in fighting other kinds of pneumonia: "Bacterial pneumonia is one of the most common causes of death in hospitals and, like plague, many of these pneumonias are caused by bacteria that grow both inside and outside the cells of our bodies."
Smiley’s studies are funded by the Trudeau Institute and grants from the National Institutes of Health. The Trudeau Institute is an independent, not-for-profit, biomedical research organization, whose scientific mission is to make breakthrough discoveries leading to improved human health. Trudeau researchers are identifying the basic mechanisms used by the immune system to combat viruses like influenza, mycobacteria, such as tuberculosis, parasites and cancer, so that better vaccines and therapies can be developed for fighting deadly disease.
The research is supported by government grants and philanthropic contributions
http://www.infectioncontroltoday.com/news/2011/01/new-discovery-could-lead-to-vaccines-for-plague-and-bacterial-pneumonias.aspx

Sunday, 19 December 2010

BIOTERRORISM: Massachusetts emergency preparedness progress may be in jeopardy

Elizabeth Cooney: December 17, 2010

Almost 10 years after the Sept. 11 terrorist attacks and the anthrax mystery mailings, state public health departments have become better prepared to face emergencies, but a new report from a national health policy group says gains made by Massachusetts and many other states may be in danger. The state’s emergency preparedness chief said the findings do not reflect current capacity.
The Trust for America’s Health and the Robert Wood Johnson Foundation compiled scores for the 50 states based on how well they prevent, identify, and respond to new disease outbreaks, threats of bioterrorism, and natural disasters. Massachusetts, regarded as the birthplace of public health, scored six out of a possible 10 points. Only two states -- Iowa and Montana -- scored lower, with five points.
Like many other states, Massachusetts has seen cuts to its public health budget, from fiscal 2008-2009 to 2009-2010, which the report’s authors link to poorer readiness. The state also fell short on how it communicated with staff during emergency exercises, developing incident reports within 60 days, and rapidly identifying and submitting results of testing for foodborne diseases caused by e. coli contamination.
“That was a snapshot of our capacity at that time but it doesn’t really reflect the changes to programs we made since then,” Mary Clark, director of the Massachusetts Emergency Preparedness Bureau, said in an interview. The report looked at 2007 and 2008, which she says is outdated.
The four issues on which the state did not meet the report’s standards were based on incomplete information or have been rectified, she said. Although the state’s public health budget has been cut, the legislature has funded emergency preparedness separately. The state now meets the two criteria for staff notification and incident reporting. And a better system is now in place for reporting foodborne illness test results to the US Centers for Disease Control and Prevention.
Rhode Island also scored six out of 10 points. Maine did slightly better with a score of seven out of 10. Connecticut, New Hampshire, and Vermont led New England with eight out of 10 points. Only Maine and New Hampshire had stable or increased funding for public health.
Clark said she sees a continued commitment to public health preparedness in Massachusetts and other states, as shown by their response to the H1N1 flu pandemic last year.
“It wasn’t as severe as it could have been. Despite the issues around vaccine availability and timeliness, Massachusetts, for example, had one of the highest rates of vaccination of all of the states in the US,” she said. “The ability to do that was based on emergency preparedness work done at the local and state level in the years since 2001.”
http://www.boston.com/news/health/blog/2010/12/mass_emergency.html

Monday, 6 December 2010

BIOTERRORISM: Wikileaks: vaccines

Though most of the information was in the public domain, its release is likely to lead to accusations that WikiLeaks did not care if it aided terrorists.

Called the Critical Foreign Dependencies Initiative, the list divides the world into six regions. It makes clear how the US depends on a range of substances from smallpox vaccines in Denmark to bauxite in Guinea and liquefied natural gas in the Middle East.
Also listed is a facility making the rabies vaccines in France and typhoid vaccines in Switzerland.

http://www.telegraph.co.uk/news/worldnews/wikileaks/8183136/Wikileaks-US-identifies-key-sites-around-world-for-security.html