Saturday, 7 December 2013

MALNUTRITION: Keeping malnutrition on radar after Typhoon Haiyan

BANGKOK, 5 December 2013 (IRIN) - Nearly one month after Typhoon Haiyanswept through the Philippines, displacing more than four million people, health experts are trying to lower the rising risk of malnutrition among 1.5 million children under five, and help hundreds of thousands of women continue breastfeeding. 
 
“What is easily seen in the aftermath of the typhoon is the destruction [of facilities, and] injuries that require emergency care… malnutrition is a silent threat, as people often do not recognize the symptoms and it is left untreated,” said Katrien Ghoos, the World Food Programme’s (WFP) nutrition officer for the Asia-Pacific.
 
Before the typhoon struck, one out of every three children under the age of five in the regions of Tacloban, Central Visayas and Cebu in the central Philippines were chronically malnourished, 33.6 percent were stunted (having a low height for their age), and 7.8 percent were wasted (having a low weight for their height), according to the 2011 National Nutrition Survey, as cited in the recently released Multi-Cluster Initial Rapid Assessment (MIRA), produced by more than 40 agencies across nine provinces.
 
So far, in the aftermath of the typhoon the national nutrition “cluster” - comprising 30 partners, including NGOs, UN agencies and government ministries - is treating about 14 cases of acute malnutrition, which occurs “when children suffer severe wasting that [may be] accompanied by swelling of the body from fluid retention”, and 118 moderate cases. Up to 5 December some 21,000 children have been screened for acute malnutrition; 172 had severe acute malnutrition and another 531 had signs of moderate acute malnutrition. 

“The nutritional status of young children and mothers may have significantly deteriorated,” Ayadil Saparbekov, the deputy coordinator for the Geneva-based Global Nutrition Cluster, told IRIN from the Philippine capital, Manila. He said diminished access to nutritious food, limited access to safe water and sanitation leading to a likely rise in water-borne infections, young children separated from their parents, and inadequate settings for breastfeeding were some of the aggravating factors.
 
Screening for malnutrition by specialized aid groups will be completed in the coming weeks, when informed post-disaster malnutrition rates will become available. Health service delivery has been hampered by the destruction of between 46 and 62 percent of all local clinics and hospitals in the Tacloban, Central Visayas, and Cebu regions, according to the MIRA released in November.
 
In addition, up to half of the medical personnel working in the affected regions were personally affected by the typhoon. “Because of the lack of food and water in the affected areas, some doctors abandoned their posts,” said Martin Parreno, the health and nutrition coordinator for the French NGO, Action Contre la Faim International (ACF).
 
"Ideally, an investment will be made [at the regional level] in the government health system, health workers, and larger-scale training for the delivery of community-based therapeutic care. [But] health services and infrastructure need to be re-established first,” WFP’s Ghoos said from Bangkok, Thailand. 
 
Rallying support for breastfeeding

 
Humanitarian health workers will now be focusing on boosting supplementary feeding for children aged 6 to 23 months in 30 municipalities on the islands of Leyte, Eastern Samar, and Western Samar. 
 
“Unless the situation in these areas is brought back to ‘normal’, a rise in acute malnutrition can be expected,” warned Ghoos.
 
Humanitarians are also worried about the uncontrolled distribution of infant formula and milk powder donations by charities and church groups, which occurs so frequently after disasters that in 1986 the Philippines government instituted a “Milk Code” banning donations of infant formula products in disasters.
 
“Donations of powdered infant formula discourage mothers to continue breastfeeding exclusively, and exacerbates the risk of morbidity and mortality among infants, which will in turn contribute to increased levels of acute malnutrition and disease,” said Saparbekov, from the global nutrition cluster.
 
Thirty breastfeeding tents will be put up this month in evacuation centres in Tacloban and the nearby region of Tanauan. Aid groups will also broadcast nutrition-related messages for half an hour on the radio each morning at 10 a.m., according to the national nutrition group.
 
Yet exacerbated malnutrition is only one aspect of the disaster’s impact on maternal and child health, say local health workers. “A newborn in [one of my colleague’s communities] died right after delivery due to lack of facilities that would attend to his condition,” Anna Sharmie Quezon, a local doctor in Central Visayas reported to the UK-based medical journal, The Lancet, on 30 November.
 
At a nutrition and food security conference held in the region in late November, health experts spotlighted the first thousand days of life after birth as critical for optimum nutrition.
 
ACF’s Parreno noted that “Damaged health facilities [are being] quickly repaired and made functioning to accommodate more patients.”
 
dm/pt/he

Tuesday, 3 December 2013

MALARIA: Reviving an old drug to block transmission

Malaria is spread from humans to mosquitoes when the parasite is in its gametocyte form
Malaria is spread from humans to mosquitoes when the parasite is in its gametocyte form
An antimalarial drug that does nothing to help patients’ symptoms may yet be the key to stopping malaria. Dr Chi Eziefula, a Wellcome Trust Clinical Fellow, explains the potential significance of her research recently published in the Lancet Infectious Diseases.
A single dose of primaquine can stop the falciparum malaria parasite being transmitted from humans to mosquitoes. The drug has no effect on the parasite stage that causes illness and death in humans, so has no role in treating malaria, but it clears the transmission stage of the parasite from the bloodstream and, since the parasite is then unable to leave the body, it cannot spread to mosquitoes and from them to other people. For decades, therefore, primaquine has been recommended by the World Health Organization (WHO) to be given in combination with standard antimalarial treatment, with the aim of eliminating this deadly parasite.
However, only a small number of countries include primaquine in their national malaria treatment policy. Primaquine has been available since the 1940s, it is low-cost, and it is the only drug widely available that effectively blocks malaria transmission. Why then, given the WHO recommendations, is it not used everywhere to block global malaria transmission?
The reason is that, in some people, primaquine causes destruction of red cells in the bloodstream, resulting in anaemia, which in some cases can be severe and damage the kidneys. This only happens in people with a deficiency in an enzyme called glucose-6-phosphate dehydrogenase (G6PD). This deficiency is the result of a gene defect which is common in areas with a high burden of malaria, and there is a lack of simple, affordable tests to diagnose it. Therefore, rather than risk harming people who might have an undiagnosed G6PD deficiency, primaquine is rarely used.
The dose of primaquine recommended by the WHO was based on data published by Alf Alving in 1960 from an experiment in just one individual. His experiment suggested that the effect of primaquine in G6PD deficiency may be dose-related. Fascinated by the distinct lack of dose-finding studies on this potentially useful drug, my colleagues and I investigated whether lower doses of primaquine would still stop malaria parasite transmission. Our hope was that we might find a lower dose that could be safely given to people with G6PD deficiency.
Dose response
A child gives a blood sample in the primaquine study
A child gives a blood sample in the primaquine study
Our trial was designed to test whether lower doses of primaquine were as good at clearing the transmission stage of the parasite as the standard WHO dose of 0.75mg/kg in children in Uganda. We tested these lower doses in children with malaria and found that a dose of 0.4mg/kg of primaquine was no worse than the standard 0.75mg/kg dose. As a safety precaution, only children with normal G6PD levels were included in this trial, and we found that all doses were safe for them; in particular, there was no significant difference in levels of anaemia in the different dose treatment arms.
This raises hope that low-dose primaquine might be deployable more widely to block malaria transmission. However, reflecting on these findings, we are several steps away from the prospect of using primaquine universally in malaria-endemic areas. We need to know now whether lower doses of primaquine are safe in people with G6PD deficiency, bearing in mind that the degree of G6PD deficiency varies greatly geographically. We also need to know how best to use primaquine to block malaria at the population level. For example, what proportion of the infected population needs to be treated, and how often, to reduce the parasite burden, and what are the ethical issues involved in giving a drug at large scale to achieve this?
It is estimated that 3.3 billion people are at risk of malaria infection globally. Annually 660 000 people die of malaria and 90% of these deaths are in Africa in children aged less than 5 years. Encouragingly, these figures represent a substantial improvement over the last decade. Sustained malaria control efforts have meant that several countries are on the brink of malaria elimination. To make elimination a reality we need to focus on tools that specifically target malaria transmission. This is even more urgent now in the context of the threat of drug-resistant malaria that is emerging in Southeast Asia.
Chi Eziefula
The primaquine study team
The primaquine study team

Reference:

ResearchBlogging.org
Eziefula AC et al (2013). Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial. The Lancet Infectious Diseases PMID: 24239324
Image credits: Chi Eziefula / Andrea Conroy (Uganda); The Wellcome Trust courtesy of RA Shooter, Wellcome Images (gametocyte).

MALARIA: why is falciparum specific to people?

From:William Brieger


 Dec 3, 2013 
Researchers have discovered why the parasite that causes the deadliest form of malaria only infects humans.
The team recently showed that the interaction between a parasite protein called RH5 and a receptor called basigin was essentially required for the invasion of red blood cells by the parasite that causes the deadliest form of malaria. Now, they've discovered that this same interaction is also an important factor in explaining why the parasite seems to be remarkably specific to humans. This research will help guide eradication strategies in regions where malaria is endemic.
There are several distinct species of parasite that cause malaria. The malaria parasite species responsible for severe illness and death, Plasmodium falciparum, only infects humans, but is closely related to several species that infect chimpanzees and gorillas. Strangely, these species seem to be very specific – individual species appear to infect only humans, chimpanzees or gorillas, even when these primates live in close proximity. This striking observation piqued the curiosity of the team which prompted a search for the molecules that controls this specificity and revealed the important role of the RH5-basigin interaction.
"It's remarkable that the interaction of a single pair of proteins can explain why the most deadly form of malaria is specific to humans" says Dr Julian Rayner, from the Wellcome Trust Sanger Institute Malaria Programme. "This research will strengthen eradication strategies by ruling out great apes as possible reservoirs of human infection by P. falciparum."
The team investigated the question of host specificity by examining two important protein interactions involved in the invasion of red blood cells - the interactions between the parasite and host EBA175-Glycophorin A and RH5-basigin.
They found that the EBA175 protein from chimpanzee specific malaria parasites could bind to human Glycophorin A, thereby ruling out this interaction as a specificity factor.
However, the RH5 protein from P. falciparum did not bind to the gorilla basigin protein and only bound extremely weakly to chimpanzee basigin. Therefore, the species specificity of this interaction mirrored the known infection profile of P. falciparum and provided a molecular explanation for why P. falciparum only infects humans.
"This interaction seems to explain why P. falciparum only infects people and not apes," says Professor Beatrice Hahn, author from the University of Pennsylvania. "This may also be an important guiding factor in the development of eradication strategies for the elimination of P. falciparum in endemic areas."
Until recently, studying protein interactions between the malaria parasite and great apes has been challenging. Both chimpanzees and gorillas are protected species and so obtaining blood samples that would help answer these questions is incredibly difficult.
"Today, we can produce these proteins synthetically in the laboratory to avoid the use of blood samples from endangered animals," says Dr Gavin Wright, lead author from the Wellcome Trust Sanger Institute. "In time, these scientific advances will lead to improved treatments, eradication strategies and, vaccine development for one of the world's major health problems."

Monday, 2 December 2013

SciDevNet Weekly update: 2 December 2013

Bringing science & global development together through news and analysis
 
Latest from global edition
 
 

Highlight

 
 
 
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See SciDev.Net's coverage on the 19th Conference of the Parties to the UNFCC.

 
 

Agriculture

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Analysis blog:
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Focus on Gender: women are more than agricultural victims

Agricultural research must put women at its heart rather than continuing the victim narrative, says Henrietta Miers.

Environment

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27/11/13

Study to bring wave of ocean data to negotiating table

The World Science Forum has heard how a team catalogued trends in ocean science, making them accessible to policymakers
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25/11/13

Progress on loss-and-damage and tech transfer at COP19

Dealing with climate impacts in developing nations may become easier with two of the outcomes of the climate talks.

Health

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Multimedia:
29/11/13

Q&A: Alvaro Bermejo on how HIV has reshaped global health policy

The head of the International HIV/AIDS Alliance discusses how HIV programmes hold lessons for other health agendas.
News:
26/11/13

Weak research capacity holds back progress on diseases

Obstacles to strengthening research capacity undermine poorer countries’ health and need action, experts say.

Governance

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Multimedia:
28/11/13

Q&A: Anne Glover on being a ‘critical friend’

The chief scientific advisor to the president of the European Commission discusses science’s role in policymaking.
Multimedia:
27/11/13

How improved technology can battle climate change

In this video, experts discuss international strategies to implement resilience in developing countries.
News:
27/11/13

Latin America’s female scientists outnumbered at the top

More women in Latin America are pursuing research careers, but men still occupy the majority of senior positions.
Opinion:
26/11/13

India must move on reforming animal welfare in research

India could lead by combining strong animal welfare law with investment in non-animal testing, say experts.
Multimedia:
26/11/13

PhDs in Focus: a Zimbabwean researcher tells her story

Dr Sithabile Tirivarombo talks to Imogen Mathers about the challenges facing researchers in Southern Africa.
Feature:
26/11/13

Africa’s young researchers have a long road ahead

Governments have to do more to help young African researchers succeed, Jan Piotrowski finds.
Multimedia:
25/11/13

A step forward on climate resilience

Last week, the 48 least developed countries submitted a set of plans to the UN to assess their adaptation needs.

Enterprise

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Focus on Private Sector: How miners can cut mercury use

Gold-mining firms in developing nations can use low-tech to limit this pollutant’s use, Joshua Howgego learns.
SciDev.Net at large:
29/11/13

Data for development: revolution kicks off in Côte d’Ivoire

European Development Days get a taste of how mobile-phone data could transform development practice.
Multimedia:
26/11/13

Using natural capital to account for nature’s services

In this video, we give a voice to speakers and activists from the World Forum on Natural Capital.

Communication

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28/11/13

Journalism contest eyes developing country entries

A competition designed to raise coverage of development issues may widen its entry criteria, says an organiser.
SciDev.Net at large:
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EU Development Days' hidden love of science

Science was not prominent in the European Development Days 2013 programme, but it still permeated the discussions.
News:
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Development journalism grants reveal science deficit

Few entries in a competition designed to boost media coverage of development issues dealt with science.