Showing posts with label Pregnancy in Malaria. Show all posts
Showing posts with label Pregnancy in Malaria. Show all posts

Friday, 3 February 2012

MALARIA: Rwanda: Malaria in Pregnancy & Elimination

 Bill Brieger : 25 Jan 2012
Malaria in Pregnancy in Rwanda as We Move Closer to Elimination
Malaria incidence and prevalence has been dropping quickly in Rwanda, below 2% in children under 5 years old. Malaria in Pregnancy (MIP) is still a risk some and may be more severe as the disease becomes rare and immunity reduces. The US President’s Malaria Initiative is supporting a prevalence study of MIP through its Maternal and Child Health Integrated Program (MCHIP) and the National Malaria Control Program (NMCP) so that appropriate data will become available to design appropriate MIP interventions as the country moves towards malaria elimination.
The study focuses on pregnant women during their first visit to focused antenatal care (FANC) for their current pregnancy. Four FANC visits promote maternal and newborn health through 1) Early detection and treatment, 2) Prevention of complications and disease, 3) Birth preparedness and 4) Health promotion.
The study of over 4000 women is at the half way mark. Supervisory visits determine if data such as RDT, Microscopy and PCR tests, are being gathered correctly.


dscn7279sm.jpg
Pictured here are Alice and Donatien who are nurses based at Gakoma Health center in Gisagara District and were trained for the the MIP prevalence study. They are seen here taking blood samples for the study. They have integrated the study procedures into the routine FANC they provide. This makes it easier for the client as well as the nurses who also extract study data on age, parity, hemoglobin, bednet ownership and fever history which is normally collected as part of FANC.

Since data collection began in late December, Alice and Donatien have enrolled about half of their target number of clients. When the results from all 38 health centers across the country are compiled in April, the National Malaria Control Program will have valuable information to plan how best to protect pregnant women as the country moves closer to malaria elimination.
http://www.malariafreefuture.org/blog/

Sunday, 24 July 2011

MALARIA: Intermittent Treatment to Prevent Pregnancy Malaria Does Not Confer Benefit in an Area of Widespread Drug Resistance

Whitney E. Harrington et al. 

Intermittent Treatment to Prevent Pregnancy Malaria Does Not Confer Benefit in an Area of Widespread Drug Resistance

Millions of African women receive sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment during pregnancy (IPTp) to avoid poor outcomes that result from malaria. However, parasites resistant to SP are widespread in parts of Africa, and IPTp may perversely exacerbate placental infections that contain SP-resistant parasites.

Methods. The study used a cross-sectional design. We determined IPTp use in a delivery cohort of 880 pregnant women in Muheza, Tanzania, by report and by plasma sulfa measurements, and we examined its effects on maternal and fetal delivery outcomes.Results. In the overall cohort, IPTp was not associated with decreased odds of placental malaria or with increased mean maternal hemoglobin or mean birth weight. Unexpectedly, IPTp was associated with decreased cord hemoglobin level and increased risk of fetal anemia, which may be related to in utero SP exposure.

Conclusions. IPTp does not improve overall pregnancy outcomes in Muheza, Tanzania, where SP-resistant parasites predominate and may increase the odds of fetal anemia. As parasite resistance increases in a community, the overall effect of IPTp may transition from net benefit to neutral or net harm.

Thursday, 9 June 2011

MALARIA: Nigeria: Pregnant women and battle against malaria


Oluwole Ige : 30 May 2011



Pregnant women at an ante-natal clinic

Malaria, from the medical point of view, is caused by female mosquito known as anopheles, which drops its Plasmodium into the system of individuals after biting. It is no respecter of status, gender and age. Besides, it is one of the highest killer-diseases in Africa. Some experts even claim that malaria kills more than the dreaded HIV/AIDS, especially in Sub-Saharan Africa. The new dimension to the scourge of the disease is its ravaging effects on the population of pregnant women in Nigeria.

Recently, the Ogun State Commissioner for Health, Dr Isiaq Salako, hinted that about 4, 500 pregnant women die of malaria in the country annually.
Though, the figure appears insignificant, considering the over 150 million population of Nigeria, it is an established fact that the disease remains a great threat to the population particularly expectant mothers.
According to Dr Adelakin Makanjuola, a consultant gynaecologist, malaria is a parasitic infection transmitted to humans through the bites of infected female anopheles mosquitoes. About 60 species of the anopheles mosquito are major transmitters of the disease. There are four different types of malaria parasites, plasmodium falciparum, P. malariae, P. ovale, and P. vivax. Within each species there are many variant strains. Worldwide, P. falciparum and vivax cause the vast majority of clinical cases and nearly all of the deaths and serious morbidity.
In Africa, P. falciparum, the most dangerous of the parasites, causes over 90 per cent of all malaria infections. So far, entomologists have identified over 2000 species of mosquito, but only the anopheles mosquito actually transmits malaria. In Africa, the major vector of malaria is An. gambiae, and there are many members of this group of mosquito. The parasite after spreading rapidly through the bloodstream to the liver, emerges again into the blood stream, finally to settle in the red blood cells, where it multiplies and emerges in bursts of new organisms.
These parasites, because of their large numbers, can cause particular damage to the nervous system, liver, and kidney. The resulting disease in humans can be devastating, especially in young children and adults including, pregnant mothers and their unborn babies as well as Nigerians in diaspora who have been away from Nigeria or other malarious zones for more than two years and have either not developed natural immunity or have lost it.
This group is also very vulnerable to cerebral malaria which can result in death within hours. Others die later from the infection either from overwhelming anaemia, liver or kidney failure. Generally speaking, with untreated malaria, up to 20 per cent of persons infected with falciparum malaria will die. The stark reality of this scourge in Nigeria is as follows: In Nigeria, there is an estimated 25 per cent -30 per cent of mortality in children under five, or an estimated 300,000 deaths each year due to malaria.
The campaign slogans aimed at battling the endemic disease are endless and their messages catchy to drive home the need to avoid environmental and sanitary conditions are, capable of fuelling the spread of the malaria. Such slogans include: “Roll back malaria; Counting malaria out; Effective malaria treatment, and Free Africa from malaria now, among others. The improper disposal of refuse, stagnant water, gross inadequate access to right medication and inability of many families to access preventive facilities like bed nets have been identified as factors aiding malaria infections.
Despite the aggressive campaigns against the disease and the huge financial and manpower commitments by the Federal Government, donor agencies, including the World Health Organisation (WHO), Global Fund and other stakeholders in the health sector, malaria continues to constitute a serious health challenge, with the 110 million clinically diagnosed cases in Nigeria annually.
From its debilitating effects, investigations by the United Nations Children Fund (UNICEF) revealed that the disease imposes a heavy social and economic burden, which resulted into a loss of about N132 billion annually in prevention, cost treatment and productivity loss in Nigeria. Such loss came in form of hours lost due to illness, deaths of members of the working population; impaired child development and absenteeism from work as a result of the disease.
Worst hit by the malaria endemic are the children and pregnant women. It adversely affects children under the age of five and pregnant women in Sub-Saharan Africa, leading to the death of nearly 3, 000 every day.
Apart from little children and infants, pregnant women are found to be highly susceptible to malaria attacks. Generally, expectant mothers have been medically proven to be four times more prone to malaria parasites than those not pregnant. Reports by medical experts indicate that when women become pregnant, their immunity and disease resistance level become low, therefore, they will be more or less helpless when malaria parasites strike.
It is not uncommon for some pregnant women, having frequent bouts of malaria fever and this has made it mandatory for them to seek medical treatment immediately, with a view to avoiding its negative consequences. Experts and consultant gynaecologists hold the view that malaria attack on pregnant women could lead to low blood pressure, premature labour, abortion, stillbirth, low weight babies, anaemia and possibly preventable death, if timely action is taken to reverse its trend.
The United Nations (UN) has done a lot in its quest to totally eradicate malaria. The Roll Back Malaria (RBM) and the Global Malaria Action Plan (GMAP) are some of the intervention strategies made by organisations and individuals to help deliver the world, including Nigeria from the shackles of malaria.
Despite the clear evidence that many pregnant women could be saved from the complications of malaria through the use of insecticide-treated nets (ITNs) and intermittent preventive treatment, many still succumb to death occasioned by malaria parasites. Towards this end, concerned health care practitioners have raised alarm, cautioning that if the situation is not checked on time, the target to checkmate the incidence of malaria in pregnancy will not be met and the gloomy pictures of the endemic disease will continue to wreck havoc on Nigerian women and their unborn babies.
The most pathetic development is that most times, the victims do not show any symptom of illness. Clinical records show that the malaria parasites attack the placenta even at low infection rates and this invasion of the placenta leads to ill health for the mother, which may precipitate abortion of the foetus as well as premature labour.
More frightening is the recent world malaria report, which indicated that Nigeria accounts for a quarter of all malaria cases in the 45 malaria-endemic countries in Africa. This revelation obviously brings to the front burner the daunting challenges of malaria in the country. Thus, pregnant women, who are identified as one of the groups at high risk of the effects of malaria infection, need special protective measures to ensure their survival and improve birth outcomes.
Therefore, sleeping under insecticide treated nets remains one of the key strategies for protecting expectant mothers and their newborns from malaria-carrying mosquitoes and seeking medical care after suspecting symptoms of malaria would also go a long way in combating the disease.
In an interview with the Nigerian Tribune, Dr Bukola Adesina, a gynaecologist, at the University College Hospital (UCH), Ibadan said malaria as a disease affects pregnant women in Nigeria, just like any other person. She described Nigeria as an endemic country as far as malaria infection is concerned.
“It is endemic in Nigeria. It is important to make a demarcation. It depends on what part of the world you are living because this determines to a large extent how you will react or respond to malaria,” she stated.
According to her, people get infected all year round, “though individuals, who live in endemic area or zone, have some level of immunity” but they still get infected after being bitten by mosquitoes that transmit malaria parasites into their body systems.
“When a woman becomes pregnant, her immunity mechanism will reduce. The malaria will live in the placenta of the woman. The placenta provides a safer abode for the malaria parasites and it is the supply link between the baby and the mother. After occupying the placenta region, malaria parasite will disturb the supply of nutrients to the baby; hence, the baby is starved and this negatively affects the weight of the baby,” Dr Adesina remarked.
While observing that Nigeria’s prenatal mortality ranked among one of the highest in the world, the gynaecologist maintained that malaria, which makes pregnant women to develop anaemia contributes to maternal mortality rate.
“It is observed that when the malaria parasite load is so much in the system of an expectant mother, the baby dies before delivery. There is no robust data capturing system in Nigeria. Worldwide, 10 per cent of maternal mortality is related to anaemia, which is a fallout of malaria,” Dr Adesina hinted.
She further listed reasons pregnant women die as a result of haemorrhage-bleeding, hypertension with seizures-convulsion, obstructed labour, abortion and infection, adding that part of the measures put in place by the federal government to combat maternal mortality include the provision of access to effective health care, Intermittent Preventive Therapy (IPT), Insecticide Treated Nets (ITNs) and prompt treatment of malaria with Artemisin Combination Therapy (ACT).
Dr Adesina, who canvassed for the effective education of the people, particularly pregnant women about the myths of malaria on the part of the government, said some people still believed erroneously that exposure to the sun could cause malaria infection, stressing the need for all to seek information about the disease.
According to her, poverty also contributed largely to the spread of malaria infection in Nigeria, advising that government should address poverty squarely as a veritable means of combating the scourge, saying that some people could not even seek medical services because of their inability to pay for the medicare.
Part of the short term measures that can be adopted by the government, Dr Adesina said, involve active collaboration with the mission homes and Traditional Birth Attendants (TBAs) because some pregnant women in Nigeria still patronise them for delivery services.
Said she, “the government should liaise with these mission homes and TBAs on the need to educate pregnant women to make use of Insecticide Treated Nets (ITNs) and create awareness about the danger that malaria poses to the health and survival of pregnant women in Nigeria”.
Continuing, Dr Adesina contended that “opinion leaders, religious groups, market women associations, civil society organisations, Non Governmental Organisations (NGOs) and health institutions are major stakeholders that government should work in synergy with to really have headway in the fight against malaria.
Some pregnant women who spoke to the Nigerian Tribune expressed concerns and fears over the debilitating effects of malaria parasites on their present status, lamenting that the infection had done irreversible damage to them in the past.
Mrs Sakirat Adebimpe regretted that she lost four months old pregnancy to malaria in 2009. She said “I do not treat malaria with kid’s gloves any longer because of the bitter experience I had in June 2009. I was attacked by malaria fever, though, I went to the hospital to treat it, I eventually had a miscarriage due to the extent of damage it had wrecked on my pregnancy then. The doctor observed that if I had reported at the hospital earlier, the malaria could not have affected the pregnancy.”
The 36 year-old woman, who is already carrying a six month pregnancy added that “nowadays, I attend ante-natal clinic regularly and if I feel or suspects any symptom of malaria, I hurriedly visit hospital to access appropriate medical services, with a view to warding off any advance from malaria parasites.”
In her own submission, Mrs Ijeoma Nwachukwu had this to say, “I have always adopted preventive measures to combat malaria. I am quite aware of the dangers that malaria poses to pregnant women and this has made it mandatory for me and my children to sleep inside Insecticide Treated Net [ITN] so as to avoid mosquitoes’ bites that cause malaria. Besides, I attend antenatal clinic and also go for medical checks regularly to avoid any untoward development”.
Several factors have been postulated as accounting for limited successes in eradicating malaria, which include lack of political will and commitment of successive Nigerian governments in tackling it, poor awareness and appreciation of the magnitude of the malaria burden right across the board, poor health facilities and practices by individuals and in communities and resistance to drugs and insecticides by malaria parasites.
http://tribune.com.ng/index.php/features/22651-pregnant-women-and-battle-against-malaria-scourge

MALARIA: Pregnancy-related malaria parasite's biochemical weakness identified

Washington, June 8 :

Researchers from the University of Copenhagen have discovered the biochemical weakness of the lethal malaria parasite - that kills 10,000 pregnant women and up to 200,000 newborn babies every year - and are in the quest to develop its vaccine target and take it through the first trials to test its safety.
"Pregnant women and children below the age of five years are particularly vulnerable to malaria because of the parasite''s survival mechanisms. The parasite has a protein hook designed to attach it to the placenta and this leads to amnesia of the mother who in worst case can die or deliver prematurely. This increases the maternal mortality - and infant mortality," explains Associate Professor Ali Salanti from the University of Copenhagen''s Centre for Medical Parasitology who manages the project.
For years, researchers have been looking for a vaccine that can attack the malaria parasite''s specific placenta hook. This is tricky not least due to the fact that the parasite''s hooks are long proteins, which are difficult to produce artificially in the lab when developing of a vaccine.
After intensive research efforts, the researchers have now succeeded in identifying a fragment of the placenta hook (VAR2CSA), which not only is crucial for the parasite’s ability to attach itself to the placenta, but also is possible to produce artificially for a vaccine.
"A vaccine must stimulate the immune system to quickly attack something foreign in the body. Therefore, it was a matter of finding the part of the placenta hook, which the parasite cannot manage without and which we could target a vaccine against," Salanti said.
http://www.newkerala.com/news/2011/worldnews-2626.html

Sunday, 15 May 2011

MALARIA: Malawi: Danger, and Risk Perceptions among the Yao in Rural Malawi

Annika Launiala1, Marja-Liisa Honkasalo2Article : 26 AUG 2010 Medical Anthropology Quarterly: Volume 24, Issue 3, pages 399–420, September 2010

Findings from a study designed to discover how local understanding of malaria among Yao in Malawi relate to pregnancy risk definitions reveal that malaria in pregnancy is not perceived as a major risk. Using extended ethnographic field research and multiple methods, we argue a shift from narrow single-disease approaches to malaria during pregnancy is required and document women's concerns about exposure to multiple vulnerabilities during pregnancy, including witchcraft, extramarital affairs, and multiple dangerous illnesses. Four dimensions are implicated in Yao perceptions of risk: perceived adverse consequences in pregnancy; ease of treatment and cure; transmission and agency to control; and type of risk (social–medical). We discuss implications and consider malaria program features needed to address the complexity of perceived vulnerabilities and living conditions in resource-poor settings.

In April 2007, one of my Malawian research assistants phoned with news of, I (principle author) thought, the expected birth of a son. He and his wife had honored me by inviting me to choose the baby's name, and I eagerly awaited news. Sadly, he said that Onni (the name I chose, happiness in Finnish) had died, only four days after birth.

We expected Onni in late May or early June. On April 5 my wife complained of fever, whereupon I advised her to seek medical attention at the Lungwena health center. There she was given SP (sulfadoxine pyrimethamine), but her condition did not improve. After three days we started to think that the situation was bad, and on April 9 she went back to the health center. From there she was referred to St. Martin's mission hospital where she delivered after a hard struggle, just barely escaping surgery, but thank God she gave birth to a baby boy who weighed 2700g. Two days later she and Onni were discharged from the hospital. The problems started at home. My wife tried to breastfeed Onni, and at first it seemed to go well. But on the following night Onni became feverish and refused to suckle at her breast. In the morning we went to the Lungwena health center from where we were again referred to St. Martin's mission hospital. After some examinations the personnel found that Onni was suffering from malaria, and his temperature kept rising. Both my wife and Onni were given some treatment and admitted to the ward. I left for home around 4 pm and at that time Onni seemed to be improving. The following morning I was getting prepared to go to the hospital when they arrived with the corpse. They told me that Onni had died during the night, April 12.

Onni's untimely death propelled deeper reflections about my presumptions that malaria is perceived by everyone in Malawi as a major problem, one with dire consequences for pregnant women and young children. Despite, perhaps because of, my prior role as a UNICEF project officer responsible for malaria prevention activities, I had not questioned the disease focus. As the need is great to reduce the heavy burden of malaria in Malawi and sub-Saharan Africa where 25 million women become pregnant annually and are at risk of malaria, which significantly contributes to maternal and neonatal morbidity and mortality (Dellicour et al. 2010; Rogerson et al. 2007). Onni's death made me wonder what factors influence women's ability and motivations for malaria prevention during pregnancy, what kinds of local perceptions of pregnancy risks and vulnerabilities women have, how malaria during pregnancy is related to them, and more importantly how they match with the “at risk” approach used by international organizations and program planners.

This article examines the multiple dimensions in local perceptions of risk and shows why the Yao people of rural Malawi do not perceive malaria in pregnancy as a major risk. We do this by moving beyond the conventional single-disease approach and explore malaria in the context of pregnancy. We pay attention to the perceived vulnerabilities—witchcraft, extramarital relationships, multiple illnesses, and worries in pregnant Yao women's everyday lives—and examine how malaria is associated with these vulnerabilities. To reach a comprehensive understanding of risk perceptions, we investigate these issues from multiple perspectives among the Yao, including those of men, older women, pregnant women, and women of reproductive age as “it is the diversity in the experience and perceptions to risk that are important” (Nichter 2003:28). The following research questions guided our research: What kinds of vulnerabilities are pregnant women perceived to be exposed to in the communities? What local illnesses are perceived to be dangerous for pregnant women, why, and is malaria among these illnesses? What are the major worries among women and men related to pregnancy?

In international health, epidemiological approaches to risk dominate. Risk is calculated as a probability in terms of the odds that something will occur (or will not occur) within a given population exposed to specific risk factors relative to a reference population and perceived risk (Frankenberg 1993:229; Gordis 2004). Frankenberg describes the risk approach in epidemiology as a way of justifying a medical intervention (1993:233). Anthropologists criticize the epidemiological risk definitions for its neglect of the sociocultural settings where risk is understood and negotiated and for failing to account for heterogeneity and variations in meanings of risk among groups (Frankenberg 1993; Lupton 1999:24; Trostle 2005:161).

Mary Douglas's pioneering work (1992) galvanized medical anthropologists to deeply engage the notion of risk, also referred to as hazard, chance, uncertainty, and danger (Lupton 1999:8–9; Nichter 2008). Advances in our understanding of risk have come as studies pursue several perspectives. Some examine risk through the notion of uncertainty and its manifestations in everyday life (Bledsoe 2002; Haram 2005; Honkasalo 2006; Whyte 1997; see also Caplan 2000). Others demonstrate how social threats and risks influence treatment-seeking and prevention practices and how they can outweigh physical and biological risks (Bujra 2000; Chapman 2006; Nichter 2003:29, 2008:58–59). According to Nichter (2003:29), it is important to notice when social risks (“risk to valued relationship” as defined by Nichter 2008:58) outweigh biologized and medicalized risk categories prioritized in public health settings. This enables us to understand why certain preventive methods are accepted and others not. It is also important to note that risks are valued and prioritized differently based on their relevance at a given time, rather than actively considered simultaneously all the time. Nichter (2008:60) refers to hierarchies of risks: “how risk is judged in context as well as in relation to other risks rather than in isolation” (see also Day 2000). Furthermore, some medical anthropologists have emphasized that a comprehensive understanding of risk perceptions and factors affecting exposure to risk also requires examination of structural forces—poverty, inequality, and livelihood insecurity—that all impinge on access to health care. In other words, risk is located in the living conditions in which it occurs and investigated in a larger framework of vulnerability and agencies of power (Farmer et al. 2006; Obrist et al. 2007; Sommerfeld et al. 2002).

There is virtually no research exploring risk perceptions of and vulnerability to malaria in pregnancy. Instead, social scientists have focused more narrowly on malaria, its meaning and influence on illness experiences, treatment-seeking practices, and prevention among children under five (Ribera et al. 2007; Williams and Jones 2004). The few social scientific studies on pregnant women and malaria have examined treatment-seeking practices (Ahorlu et al. 2007), use of antenatal services (Launiala and Honkasalo 2007; Ndyomugyenyi et al. 1998), compliance with intermittent preventive treatment in pregnancy (Helitzer-Allen et al. 1994; Launiala and Honkasalo 2007; Mbonye et al. 2006; Mnyika et al. 1995), and perceptions of malaria in pregnancy (Launiala and Kulmala 2006; Winch et al. 1996). Yet, understanding experiences of vulnerability and perceived risks in a particular sociocultural and structural context are important as they influence how people respond to public health interventions such as prevention of malaria in pregnancy (Nichter 2008:11, 50).
http://onlinelibrary.wiley.com/doi/10.1111/j.1548-1387.2010.01111.x/full

Saturday, 2 April 2011

MALARIA: symptoms in pregnant women in Benin

Background
It is generally agreed that in high transmission areas, pregnant women have acquired a partial immunity to malaria and when infected they present few or no symptoms. However, longitudinal cohort studies investigating the clinical presentation of malaria infection in pregnant women in stable endemic areas are lacking, and the few studies exploring this issue are unconclusive.

Methods
A prospective cohort of women followed monthly during pregnancy was conducted in three rural dispensaries in Benin from August 2008 to September 2010. The presence of symptoms suggestive of malaria infection in 982 women during antenatal visits (ANV), unscheduled visits and delivery were analysed. A multivariate logistic regression was used to determine the association between symptoms and a positive thick blood smear (TBS).

Results
During routine ANVs, headache was the only symptom associated with a higher risk of positive TBS (aOR=1.9; p<0.001). On the occasion of unscheduled visits, fever (aOR=5.2; p<0.001), headache (aOR=2.1; p=0.004) and shivering (aOR=3.1; p<0.001) were significantly associated with a malaria infection and almost 90% of infected women presented at least one of these symptoms. Two thirds of symptomatic malaria infections during unscheduled visits occurred in late pregnancy and long after the last intermittent preventive treatment dose (IPTp).

Conclusion
The majority of pregnant women were symptomless during routine visits when infected with malaria in an endemic stable area. The only suggestive sign of malaria (fever) was associated with malaria only on the occasion of unscheduled visits. The prevention of malaria in pregnancy could be improved by reassessing the design of IPTp, i.e. by determining an optimal number of doses and time of administration of anti-malarial drugs
http://www.malariajournal.com/content/10/1/72

MALARIA: Tanzania: national campaign to distribute nine million free LLINs

Background
After a national voucher scheme in 2004 provided pregnant women and infants with highly subsidized insecticide-treated nets (ITNs), use among children under five years (U5s) in mainland Tanzania increased from 16% in 2004 to 26.2% in 2007. In 2008, the Ministry of Health and Social Welfare planned a catch-up campaign to rapidly and equitably deliver a free long-lasting insecticidal net (LLIN) to every child under five years in Tanzania.

Methods
The ITN Cell, a unit within the National Malaria Control Programme (NMCP), coordinated the campaign on behalf of the Ministry of Health and Social Welfare. Government contractors trained and facilitated local government officials to supervise village-level volunteers on a registration of all U5s and the distribution and issuing of LLINs. The registration results formed the basis for the LLIN order and delivery to village level. Caregivers brought their registration coupons to village issuing posts during a three-day period where they received LLINs for their U5s. Household surveys in five districts assessed ITN ownership and use after the campaign.

Results
Nine donors contributed to the national campaign that purchased and distributed 9.0 million LLINs at an average cost of $7.07 per LLIN, including all campaign-associated activities. The campaign covered all eight zones of mainland Tanzania, the first region being covered separately during an integrated measles / malaria LLIN distribution in August 2008, and was implemented one zone at a time from March 2009 until May 2010. ITN ownership at household level increased from Tanzania's 2008 national average of 45.7% to 63.4%, with significant regional variations. ITN use among U5s increased from 28.8% to 64.1%, a 2.2-fold increase, with increases ranging from 22.1-38.3% percentage points in different regions.

Conclusion
A national-level LLIN distribution strategy that fully engaged local government authorities helped avoid additional burden on the healthcare system. Distribution costs per net were comparable to other public health interventions. Particularly among rural residents, ITN ownership and use increased significantly for the intended beneficiaries. The upcoming universal LLIN distribution and further behaviour change communication will further improve ITN ownership and use in 2010-2011.
http://www.malariajournal.com/content/10/1/73

Wednesday, 23 March 2011

MALARIA: Parity and Placental Infection Affect Antibody Responses against Plasmodium falciparum during Pregnancy

Parity and Placental Infection Affect Antibody Responses against Plasmodium falciparum during Pregnancy
Infection and Immunity, April 2011, p. 1654-1659, Vol. 79, No. 4

Alfredo Mayor,1,2,3* Eduard Rovira-Vallbona,1,3 Sonia Machevo,2 Quique Bassat,1,2,3 Ruth Aguilar,1,2 Llorenç Quintó,1,3 Alfons Jiménez,1 Betuel Sigauque,1,2 Carlota Dobaño,1,2,3 Sanjeev Kumar,4 Bijender Singh,4 Puneet Gupta,4 Virander S. Chauhan,4 Chetan E. Chitnis,4 Pedro L. Alonso,1,2,3 and Clara Menéndez1,2,3

Women are at higher risk of Plasmodium falciparum infection when pregnant. The decreasing risk of malaria with subsequent pregnancies is attributed to parity-dependent acquisition of antibodies against placental parasites expressing variant surface antigens, VAR2CSA, that mediate placental sequestration through adhesion to chondroitin sulfate A (CSA). However, modulation of immunity during pregnancy may also contribute to increase the risk of malaria. We compared antibody responses among 30 Mozambican primigravidae and 60 multigravidae at delivery, 40 men, and 40 children. IgG levels were measured against the surface antigens of erythrocytes infected with P. falciparum isolated from 12 pregnant women (4 placental and 8 peripheral blood isolates) and 26 nonpregnant hosts. We also measured IgG levels against merozoite recombinant antigens and total IgG. Placental P. falciparum infection was associated with increased levels of total IgG as well as IgG levels against merozoite antigens and parasite isolates from pregnant and nonpregnant hosts. We therefore stratified comparisons of antibody levels by placental infection. Compared to multigravidae, uninfected primigravidae had lower total IgG as well as lower levels of IgGs against peripheral blood isolates from both pregnant and nonpregnant hosts. These differences were not explained by use of bed nets, season at delivery, neighborhood of residence, or age. Compared to men, infected primigravidae had higher levels of IgGs against isolates from pregnant women and CSA-binding lines but not against other isolates, supporting the concept of a pregnancy-specific development of immunity to these parasite variants. Results of this study show that parity and placental infection can modulate immune responses during pregnancy against malaria parasites.
http://iai.asm.org/cgi/content/abstract/79/4/1654

Saturday, 8 January 2011

MALARIA: Intermittent Screening and Treatment versus Intermittent Preventive Treatment of Malaria in Pregnancy: A Randomised Controlled Non-Inferiority Trial.

PLoS One. 2010 Dec 28;5(12):e14425.: Tagbor H, Bruce J, Agbo M, Greenwood B, Chandramohan D.

BACKGROUND: The effectiveness of intermittent preventive treatment of malaria in pregnancy (IPTp) may be compromised by the spread of resistance to sulphadoxine/pyrimethamine (SP) across Africa. But little informtion exists on alternative drugs for IPTp or alternative strategies for the prevention of malaria in pregnancy. Therefore, we have investigated whether screening with a rapid diagnostic test and treatment of those who are positive (IST) at routine antenatal clinic attendances is as effective and as safe as SP-IPTp in pregnant women.

METHODS AND FINDINGS: During antenatal clinic sessions in six health facilities in Ghana held between March 2007 and September 2007, 3333 pregnant women who satisfied inclusion criteria were randomised into three intervention arms (1) standard SP-IPTp, (2) IST and treatment with SP or (3) IST and treatment with amodiaquine+artesunate (AQ+AS). All women received a long-lasting insecticide treated net. Study women had a maximum of three scheduled follow-up visits following enrolment. Haemoglobin concentration and peripheral parasitaemia were assessed between 36 and 40 weeks of gestation. Birth weight was measured at delivery or within 72 hours for babies delivered at home. Parasite prevalence at enrolment in primigravidae and in multigravidae was 29.6% and 10.2% respectively. At 36-40 weeks of gestation the prevalence of asymptomatic parasitaemia was 12.1% in study women overall and was very similar in all treatment groups. The risk of third trimester severe anaemia or low birth weight did not differ significantly between the three treatment groups regardless of gravidity. IST with AQ+AS or SP was not inferior to SP-IPTp in reducing the risk of low birth weight (RD = -1.17[95%CI; -4.39-1.02] for IST-SP vs. SP-IPTp and RD = 0.78[95%CI; -2.11-3.68] for IST-AQAS vs. SP-IPTp); third trimester severe anaemia (RD = 0.29[95%CI; -0.69-1.30] for IST-SP vs. SP-IPTp and RD = -0.36[95%CI;-1.12-0.44] for IST-AQAS vs. SP-IPTp).

CONCLUSION: The results of this study suggest that in an area of moderately high malaria transmission, IST with SP or AS+AQ may be a safe and effective strategy for the control of malaria in pregnancy. However, it is important that these encouraging findings are confirmed in other geographical areas and that the impact of IST on placental malaria is investigated.



TRIAL REGISTRATION: ClinicalTrials.gov NCT00432367 [NCT00432367].



http://www.ncbi.nlm.nih.gov/pubmed/21203389

Wednesday, 15 December 2010

MALARIA: Uganda Malaria Indicator Survey shows progress - is it enough?

 Bill Brieger : 14 Dec 2010

The Uganda Malaria Indicator Survey for 2009 is now available for reading. The report helpfully provides charts that distinguish levels of key indicators from the 2006 Uganda Demographic and Health Survey with the current data. While there has been clear progress, most indicators fall below the 80% targets set by the Roll Back Malaria Partnership for 2010.

uganda-mis-2009-nets.jpg

The chart of the right shows that sleeping under any insecticide treated bed net the night prior to interview tripled for children under five years of age and quadrupled for pregnant women, the 2009 levels do not achieve RBM goals. Even when one looks only at households that actually possess these treated nets, one finds that use is less than ideal.



The report provides some reasons for low net usage…
The most common reason cited for non-usage was that the net was not hung (58 percent of households), especially in North East region (99 percent). Sixteen percent reported that the net was not used because it was too hot, and 11 percent said the net had too many holes or was too old.
There were also wide variations in ownership and use across different parts of the country, meaning that program managers need to look more indepth at possible regional factors that discourage access to and use of nets.
The East African countries were among the pioneers to introduce intermittent preventive treatment with sulphadoxine-pyrimethamine for pregnant women. Again we see that RBM targets are far from being met in Uganda, although progress over 2006 is evident.

16% of pregnant women got two doses in 2006
45% got one dose in 2009
32% got two doses in 2009
95% of pregnant women attended ANC with a skilled provider at least once in 2009

Clearly problems of procurement, supply and stock keeping and missed opportunities are preventing achievement of this goal.
The malaria case management picture was not cheering. Among children under five years of age with a reported fever in the two weeks before the survey …
60% took any antimalarial drug
23% of took an ACT
14% took ACT same or next day
Chloroquine and SP were still being used
Uganda is not in a unique situation. Even countries benefiting from the Global Fund, the US President’s Malaria Initiative and other major partners like Unicef, DfID and the WOld Bank are having a challenging time with managing commodities, improving service quality and attracting clients to avail themselves of malaria services.

2010 ends in 17 days. How many places will have achieved the RBM 80% targets? More importantly, what can the international partnership do to meet the needs?
http://www.malariafreefuture.org/blog/?p=1115

Friday, 10 December 2010

MALARIA: mefloquine as a 21st century malaria chemoprophylaxis

Patricia Schlagenhauf , Miriam Adamcova , Loredana Regep , Martin T Schaerer and Hans Georg Rhein
Malaria Journal 2010, Published: 9 December 2010

Background
Malaria chemoprophylaxis prevents the occurrence of the symptoms of malaria. Travellers to high-risk Plasmodium falciparum endemic areas need an effective chemoprophylaxis.

Methods
A literature search to update the status of mefloquine as a malaria chemoprophylaxis.

Results
Except for clearly defined regions with multi-drug resistance, mefloquine is effective against the blood stages of all human malaria species, including the recently recognized fifth species, Plasmodium knowlesi. New data were found in the literature on the tolerarability of mefloquine and the use of this medication by groups at high risk of malaria.

Discussion
Use of mefloquine for pregnant women in the second and third trimester is sanctioned by the WHO and some authorities (CDC) allow the use of mefloquine even in the first trimester. Inadvertent pregnancy while using mefloquine is not considered grounds for pregnancy termination. Mefloquine chemoprophylaxis is allowed during breast-feeding. Studies show that mefloquine is a good option for other high-risk groups, such as long-term travellers, VFR travellers and families with small children. Despite a negative media perception, large pharmaco-epidemiological studies have shown that serious adverse events are rare. A recent US evaluation of serious events (hospitalization data) found no association between mefloquine prescriptions and serious adverse events across a wide range of outcomes including mental disorders and diseases of the nervous system. As part of an in-depth analysis of mefloquine tolerability, a potential trend for increased propensity for neuropsychiatric adverse events in women was identified in a number of published clinical studies. This trend is corroborated by several cohort studies that identified female sex and low body weight as risk factors.

Conclusion
The choice of anti-malarial drug should be an evidence-based decision that considers the profile of the individual traveller and the risk of malaria. Mefloquine is an important, first-line anti-malarial drug but it is crucial for prescribers to screen medical histories and inform mefloquine users of potential adverse events. Careful prescribing and observance of contraindications are essential. For some indications, there is currently no replacement for mefloquine available or in the pipeline.

http://www.malariajournal.com/content/9/1/357

Friday, 15 October 2010

MALARIA: Malaria 'May Increase African Women's Susceptibility to HIV and Aids'

5 October 2010
New research has revealed common infections such as malaria can make women in Africa more susceptible to HIV and AIDS.
Scientists compared immune cells in the genital tracts from women in Kenya and the US and found those living in the African nation had higher rates of activated cells, All Africa reports.
Normal cells can reach this state as a result of infection and they increase a person's vulnerability to a HIV attack, the news provider explains.
Writing in the journal AIDS, Craig Cohen from the University of California, San Francisco, said: "We believe that these findings should also start to dispel some of the preconceptions and stigma surrounding HIV acquisition among young women in sub-Saharan Africa."
This is the first time that a study has shown African females can have more activated cells in their genital tract and it could be one of the reasons why infection rates are higher in the continent than other locations in the world, the investigation explained.
Meanwhile, Health Minister Aaron Motsoaledi said more needs to be done to stop the spread of non-communicable diseases in developing countries, Times Live reported.
http://allafrica.com/stories/201010060900.html

MALARIA: Diagnosis in pregnancy

Background
New diagnostic tools for malaria are required owing to the changing epidemiology of malaria, particularly among pregnant women in sub-Saharan Africa. Real-time PCR assays targeting Plasmodium falciparum lactate dehydrogenase (pfldh) gene may facilitate the identification of a high proportion of pregnant women with a P. falciparum parasitaemia below the threshold of microscopy. These molecular methods will enable further studies on the effects of these submicroscopic infections on maternal health and birth outcomes.
Methods
The pfldh real-time PCR assay and conventional microscopy were compared for the detection of P. falciparum from dried blood spots and blood smears collected from the peripheral blood of 475 Malawian women at delivery. A cycle threshold (Ct) of the real-time PCR was determined optimizing the sensitivity and specificity of the pfldh PCR assay compared to microscopy. A real-time PCR species-specific assay was applied to identify the contribution to malaria infections of three Plasmodium species (P. falciparum Plasmodium ovale and Plasmodium malariae) in 44 discordant smear and pfldh PCR assay results.
Results
Of the 475 women, P. falciparum was detected in 11 (2.3%) by microscopy and in 51 (10.7%) by real-time PCR; compared to microscopy, the sensitivity of real-time PCR was 90.9% and the specificity 91.2%. If a Ct value of 38 was used as a cut-off, specificity improved to 94.6% with no change in sensitivity. The real-time PCR species-specific assay detected P. falciparum alone in all but four samples: two samples were mixed infections with P. falciparum and P. malariae, one was a pure P. malariae infection and one was a pfldh PCR assay-positive/species-specific assay-negative sample. Of three P. malariae infections detected by microscopy, only one was confirmed by the species-specific assay.
Conclusions
Although microscopy remains the most appropriate method for clinical malaria diagnosis in field settings, molecular diagnostics such as real-time PCR offer a more reliable means to detect malaria parasites, particularly at low levels. Determination of the possible contribution of these submicroscopic infections to poor birth outcomes and maternal health is critical. For future studies to investigate these effects, this pfldh real-time PCR assay offers a reliable detection method.
http://www.malariajournal.com/content/9/1/269

MALARIA: Artemisinin Combo as Effective as Quinine for Treating Pregnant Women With Malaria in Africa

 October 5, 2010 -- A combination of the drugs artemether and lumefantrine are safe and as effective as oral quinine for the treatment of uncomplicated malaria in pregnancy in Uganda, providing rapid parasitic clearance and a cure rate of greater than 95%, according to a study published early online and appearing in an upcoming edition of The Lancet Infectious Diseases. Quinine is considered to be a safe antimalarial treatment during pregnancy but its many adverse side-effects result in poor compliance. In 2006, the World Health Organization (WHO) recommended the use of artemisinin combination therapies (ACTs) for pregnant women during the second and third trimesters. However, there is little research comparing the effects of different drug regimes in pregnancy, and most studies have been conducted in southeast Asia, where malaria transmission rates are low. Few drug trials have been done in regions of Africa in which malaria is endemic.
In this study, an international team led by Patrice Piola, MD, Epicentre in France and the University of Oxford, Oxford, United Kingdom, investigated whether the most widely used ACT, artemether-lumefantrine, can be used as safely and effectively as quinine for the treatment of pregnant women with uncomplicated malaria in east Africa.
A total of 304 women in the second and third trimesters of pregnancy were enrolled from antenatal clinics in Uganda and randomly assigned, 152 to each treatment group. Women were assessed for parasitological failure and gametocyte carriage at weekly intervals after the start of treatment up to day 42. At delivery or day 42 (whichever came later), PCR was used to measure whether each treatment had cured new infections.
At day 42, 99.3% of patients taking artemether-lumefantrine were cured compared with 97.6% taking quinine.......
http://www.docguide.com/news/content.nsf/news/852576140048867C852577B3007E67CB

Wednesday, 15 September 2010

13 September 2010
Trends in Parasitology, Volume 26, Issue 8, August 2010, Pages 412-419Lars Hviid, Claudio R.F. Marinho, Trine Staalsoe1 and Carlos Penha-Gonçalves

Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.
http://www.malarianexus.com/articles/read/79/of-mice-and-women-rodent-models-of-placental-malaria/

Thursday, 2 September 2010

MALARIA: Safety of artemether-lumefantrine in pregnant women with malaria

1 September 2010
Background
Safety data regarding exposure to artemisinin-based combination therapy in pregnancy are limited. This prospective cohort study conducted in Zambia evaluated the safety of artemether-lumefantrine (AL) in pregnant women with malaria.
Methods
Pregnant women attending antenatal clinics were assigned to groups based on the drug used to treat their most recent malaria episode (AL vs. sulphadoxine-pyrimethamine, SP). Safety was assessed using standard and pregnancy-specific parameters. Post-delivery follow-up was six weeks for mothers and 12 months for live births. Primary outcome was perinatal mortality (stillbirth or neonatal death within seven days after birth).
Results
Data from 1,001 pregnant women (AL n=495; SP n=506) and 933 newborns (AL n=466; SP n=467) showed: perinatal mortality (AL 4.2%; SP 5.0%), comprised of early neonatal mortality (each group 2.3%), stillbirths (AL 1.9%; SP 2.7%); preterm deliveries (AL 14.1%; SP 17.4% of foetuses); and gestational age-adjusted low birth weight (AL 9.0%; SP 7.7%). Infant birth defect incidence was 1.8% AL and 1.6% SP, excluding umbilical hernia. Abortions prior to antenatal care could not be determined: abortion occurred in 4.5% of women treated with AL during their first trimester; none were reported in the 133 women exposed to SP and/or quinine during their first trimester. Overall development (including neurological assessment) was similar in both groups.
Conclusions
These data suggest that exposure to AL in pregnancy, including first trimester, is not associated with particular safety risks in terms of perinatal mortality, malformations, or developmental impairment. However, more data are required on AL use during the first trimester.
http://www.malariajournal.com/content/9/1/249