Saturday, 12 June 2010

MALARIA: PROTECTIVE EFFICACY OF INTERVENTIONS FOR PREVENTING MALARIA MORTALITY IN CHILDREN IN PLASMODIUM FALCIPARUM ENDEMIC AREAS

We estimate the protective efficacy of insecticide-treated mosquito nets and indoor-residual spraying on reducing malaria-attributable mortality 1–59 months to be 55%, with a range of 49–61%, in Plasmodium falciparum settings.
We estimate malaria prevention interventions in pregnancy (intermittent preventive therapy and insecticide-treated mosquito nets) to have a pooled protective efficacy of 35% (95% confidence interval: 23–45%) on reducing the prevalence of low birth weight in the first or second pregnancy in areas of stable Plasmodium falciparum transmission.
These data support the continued scale-up of these malaria prevention interventions in endemic settings that will prevent a considerable number of child deaths due directly and indirectly to malaria.
These protective efficacy estimates will allow the use of the LiST model for estimating the likely impact of past intervention scale-up, as well as for predicating future impact of intervention scale-up by national malaria control programs.

http://ije.oxfordjournals.org/cgi/content/full/39/suppl_1/i88?view=long&pmid=20348132

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