A pair of studies conducted by NIAID grantees at the University of Notre Dame recently found evidence of emerging speciation between two forms of Anopheles gambiae mosquitoes, M and S. NIAID-funded researchers examined the relationship between M and S and the TEP1 gene in a new study published last month.
In a genome-wide comparison of the emerging species, researchers found one allele of TEP1 that exists almost exclusively in M and not in S mosquitoes, even in areas where M and S co-exist, and showed that this allele confers resistance to rodent and human malaria parasites. Although the resistance conferred by TEP1 variants is not specific to malaria parasites, and probably did not evolve in response to malaria infection in the adult mosquito, it may still affect malaria transmission and control.
http://www.niaid.nih.gov/topics/Malaria/research/Pages/anophelesGambiae.aspx.
In a genome-wide comparison of the emerging species, researchers found one allele of TEP1 that exists almost exclusively in M and not in S mosquitoes, even in areas where M and S co-exist, and showed that this allele confers resistance to rodent and human malaria parasites. Although the resistance conferred by TEP1 variants is not specific to malaria parasites, and probably did not evolve in response to malaria infection in the adult mosquito, it may still affect malaria transmission and control.
http://www.niaid.nih.gov/topics/Malaria/research/Pages/anophelesGambiae.aspx.
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