MALARIA: Weekly Update from Malaria Nexus

Posted on 22 February 2013 The spiroindolone antimalarials kill Plasmodium by salt overdose A study published in the latest issue of Cell Host & Microbe shows that a sodium efflux ATPase is the target of the spiroindolones.   Posted on 22 February 2013 “Young” Plasmodium parasites are less sensitive to artemisinin Researchers recently reported in The Proceedings of the National Academy of Sciences that ring-stage parasites are less drug-sensitive than trophozoites.   Feature Articles   Posted on 22 February 2013 Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials Cell Host & Microbe, Volume 13, Issue 2, 13 February 2013, Pages 227-237 Natalie J. Spillman, Richard J.W. Allen, Case W. McNamara, Bryan K.S. Yeung, Elizabeth A. Winzeler, Thierry T. Diagana, Kiaran Kirk   Posted on 22 February 2013 Circadian rhythms and endocrine functions in adult insects Journal of Insect Physiology, Volume 59, Issue 1, January 2013, Pages 56-69 Guy Bloch, Esther Hazan, Ada Rafaeli   Posted on 22 February 2013 Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats Molecular and Biochemical Parasitology, Volume 187, Issue 2, February 2013, Pages 103-110 Karen Hayton, Peter Dumoulin, Bruce Henschen, Anna Liu, Janni Papakrivos, Thomas E. Wellems   Posted on 22 February 2013 Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian... International Journal for Parasitology: Drugs and Drug Resistance, Volume 3, December 2013, Pages 45-50 Bismarck Dinko, Mary C. Oguike, John A. Larbi, Teun Bousema, Colin J. Sutherland

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