The vaccine efficacy reported following Mycobacterium bovis Bacillus Calmette Guerin (BCG) administration to UK adolescents is 77% and defining the cellular immune response in this group can inform us as to the nature of effective immunity against tuberculosis. The aim of this study was to identify which cytokines and lymphocyte populations characterise the peripheral blood cellular immune response following BCG vaccination.
Results: Diluted blood from before and after vaccination was stimulated with Mycobacterium tuberculosis purified protein derivative for 6 days, after which soluble biomarkers in supernatants were assayed by multiplex bead array.Ten out of twenty biomarkers measured were significantly increased (p<0.0025) n="12)" n="12).Intracellular">
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mycobacterium_tuberculosis_ppd_induced_immune_biomarkers_measurable_in_vitro_following_bcg_vaccination_of_uk_adolescents_by_multiplex_bead_array_and_intracellular_cytokine_staining.html
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